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Allele dropout occurs when a sample is typed and one or more alleles are not present.
This can be due to a variety of factors:
- The initial input quantity of DNA is too low, resulting in the failure to amplify one or more alleles in the sample.
- A mutation in the primer binding site is present, which causes a failure in the amplification of the allele.
- An allele sizes outside of the normal calling range for a particular locus and goes undetected.
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- DNA – A Prosecutor’s Practice Notebook
- Crime Scene and DNA Basics
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- DNA Amplification
- Population Genetics and Statistics
- Non-STR DNA Markers: SNPs, Y-STRs, LCN and mtDNA
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- Forensic DNA Education for Law Enforcement Decisionmakers
- What Every Investigator and Evidence Technician Should Know About DNA Evidence
- Principles of Forensic DNA for Officers of the Court
- Law 101: Legal Guide for the Forensic Expert
- Laboratory Orientation and Testing of Body Fluids and Tissues
- DNA Extraction and Quantitation
- STR Data Analysis and Interpretation
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- Español for Law Enforcement
- Amplified DNA Product Separation for Forensic Analysts