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DNA Amplification for Forensic Analysts


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In the United States, the Federal Bureau of Investigation (FBI) bears the responsibility for maintenance of the national DNA database. The FBI worked with the relevant scientific communities to identify appropriate markers for STR DNA analysis. The European Network of Forensic Science Institutes (ENFSI) performed a similar role in Europe.

The steps involved in the selection of loci are:

Position of Forensic STR Markers on Human Chromosomes
National Institute of Justice (see reuse policy).

The selection of a core set of loci by the forensic science community must include consideration of method development. Multiplex systems are complex, and while certain loci may be more desirable than others, loci are selected based on their suitability in a multiplex system and their discriminating power.

Currently, a few manufacturers develop STR multiplex kits for mainstream forensic science use. Historically, the manufacturers and the forensic science community have collaborated to develop suitable end products. This has greatly benefited the forensic science community because it is unlikely that these laboratories would be able to devote the resources required for multiplex method development.

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