Population Genetic Issues for Forensic DNA Profiles

As submitted by the proposer:

Under this project, the investigators will continue working to produce statistical procedures for providing quantitative strength to DNA evidence. Their work will extend population genetic theory for accommodating population structure in calculating match probabilities for autosomal and lineage markers, and combinations of these markers. The researchers will also employ advanced statistical procedures for using peak heights in electropherograms in order to accommodate allelic drop-out and drop-in in situations with single or multiple contributors, and for Y-chromosome markers.

The new statistical techniques to be developed will emphasize the need for realistic run times for casework mixture interpretation. The investigators will also address the population genetic issues arising from the forensic use of next-generation sequencing. Improvements will be sought for current methods of inferring STR profiles from sequence data, and attention will be paid to determining the appropriate value of theta to determine match probabilities for sequence-derived profile.

The primary outcome of the proposed work will be peer-reviewed publications, although the work will inform the investigators’ many teaching activities and service on forensic advisory panels and editorial boards.

Note: This project contains a research and/or development component, as defined in applicable law, and complies with Part 200 Uniform Requirements - 2 CFR 200.210(a)(14).

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