The interpretation of mixed profiles from DNA evidentiary material is one of the more challenging duties of the forensic scientist. Traditionally, analysts have used a "binary" approach to interpretation where inferred genotypes are either included or excluded from the mixture using a stochastic threshold and other biological parameters such as heterozygote balance, mixture ratio, and stutter ratios. As the sensitivity of STR multiplexes and capillary electrophoresis instrumentation improved over the past 25 years, coupled with the change in the type of evidence being submitted for analysis (from high quality and quantity [often single-source] stains to low quality and quantity [often mixed] "touch" samples), the complexity of DNA profile interpretation has equally increased. (publisher abstract modified)
Downloads
Similar Publications
- Identification of Cadaveric Liver Tissues Using Thanatotranscriptome Biomarkers
- The Study of Tissue-Specific DNA Methylation as a Method for the Epigenetic Discrimination of Forensic Samples
- The Collection, Preservation, and Processing of DNA Samples from Decomposing Human Remains for More Direct Disaster Victim Identification (DVI)