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Internal Validation of STRmix (TM) - A Multi Laboratory Response to PCAST

NCJ Number
Forensic Science International: Genetics Volume: 34 Dated: May 2018 Pages: 11-24
Date Published
May 2018
14 pages

This article reports on a large compilation of the internal validations of the probabilistic genotyping software STRmix.


Thirty-one laboratories contributed data, resulting in 2,825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed, including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. The study was unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number. (publisher abstract modified)

Date Published: May 1, 2018