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Vapor Pressure Measurements on Linalool Using a Rapid and Inexpensive Method Suitable for Cannabis-Associated Terpenes

NCJ Number
Journal of Chemical and Engineering Data Volume: 68 Issue: 12 Dated: 2023 Pages: 3289-3297
Date Published
9 pages

This study demonstrates the use of a gas-saturation method known as dynamic vapor microextraction (DVME) for vapor pressure (psat) measurements.


Vapor pressure (psat) data are needed to assess the potential use of terpenes as breath markers of recent cannabis use. In this study, a recently introduced gas-saturation method for vapor pressure (psat) measurements, known as dynamic vapor microextraction (DVME), was used to measure psat for the terpene (±)-3,7-dimethylocta-1,6-dien-3-ol, commonly known as linalool. The authors demonstrate that DVME produces accurate results for values of psat that are 200 times higher than in the DVME validation study with n-eicosane (C20H42). The oxidative stability of linalool was improved by the addition of 0.2 mass % of the antioxidant tert-butylhydroquinone. The DVME apparatus utilizes inexpensive and commercially available components, a low internal volume, and helium carrier gas to minimize nonideal mixture behavior. In the temperature range from 314 to 354 K, DVME-based measurements of the psat of linalool ranged from 81 to 1250 Pa. With a measurement period of 30 min, the combined standard uncertainty of these measurements ranged from 0.0358·psat to 0.0584·psat depending on temperature. The DVME-based measurements agree with a Wagner correlation of the available literature data. (Published Abstract Provided)

Date Published: January 1, 2023