Marijuana

Of recent, forensic toxicology laboratories have been grappling with the emergence of tetrahydrocannabinol isomers within biological specimens. Traditional methodologies are often inadequate in the separation of Δ9-tetrahydrocannabinol and Δ8-tetrahydrocannabinol, which are the most common isomers identified in forensic testing.

This presentation describes the nature of the merge of the e-cigarette and cannabis industries. Quality assurance issues as a result of the absence of regulation and oversight is described. Cases of self-reported adverse events and the challenges of cannabis product analysis are also discussed.

This webinar was hosted by the NIJ Forensic Technology Center of Excellence on June 29, 2023. 

With the passage of the 2018 Agricultural Improvement Act (Farm Bill), forensic laboratories have been tasked with differentiating seized cannabis samples as either hemp or marijuana. The new legislation declassified hemp as a Schedule 1 drug substance and defined it as cannabis containing 0.3 % or less of decarboxylated-Δ9-THC (total Δ9-THC). The National Institute of Standards and Technology (NIST) has been working to help forensic laboratories with these challenging measurements through the development of extraction protocols and analytical methods.

The reauthorization of hemp due to the Agriculture Improvement Act of 2018 (Farm Bill) has caused a proliferation of products that contain cannabidiol (CBD). While CBD is considered ‘legal’ under the Farm-Bill, there are concerns that the labeling of CBD products is inaccurate, and that the products may contain other cannabinoids, including Δ9-tetrahydrocannabinol (THC), the main psychoactive compound in marijuana. Other concerns include the potential for conversion of CBD to other cannabinoids during analysis of biological matrices and in acidic foods and beverages.

As evident by the Cannabinoid Conundrums webinar series, the rapidly changing world of cannabinoids offers many conundrums. To tackle some of these questions, Dr. Ruth Winecker led a panel discussion with Dr. Ed Cone, Dr. Nathalie Desrosiers, Mr. Justin Poklis, and Mr. Nelson Santos. This diverse slate of thought leaders includes experts in analytical chemistry, forensic toxicology, clinical research, and drug chemistry. This webinar was hosted by the NIJ Forensic Technology Center of Excellence on August 3, 2023. 

Controlled drug administration studies are valuable tools for acquiring a detailed understanding of the pharmacodynamic and pharmacokinetic profiles of cannabinoids. ∆9-tetrahydrocannabinoid (THC) is the primary psychoactive cannabinoid in cannabis with the potential to negatively impact cognitive and psychomotor performance and workplace safety. These studies establish behavioral and subjective effect profiles while simultaneously collecting pharmacokinetics data.