Paper microfluidics is a transformational technology that enables the development of inexpensive analytical devices based on designs printed in wax-based ink on chromatography paper. These devices eliminate the need for bulky and sometimes caustic liquid reagents and are not much larger than a postage stamp. With NIJ support, Dr. Bruce McCord at Florida International University has developed a suite of paper microfluidic devices for forensic residue analysis applications, such as presumptive testing of explosives, serological stains, and detection of seized drugs. These devices have been validated by the Miami Dade Bomb Squad and are currently being explored for commercial forensic applications. Dr. McCord and colleagues are continuing to advance the detection capabilities for drugs and bodily fluids by broadening the range of analyte detection while improving the technique’s sensitivity. The McCord group is seeking partners who are interested in field-testing validation and advancing the commercial application of these multiplexed and field-based presumptive tests for crime-scene and laboratory investigators.