The study found that a set of 3000 SNPs specifically selected for this purpose can accurately identify the presence of an individual in complex DNA mixtures of various compositions; for example, individuals contributing as little as 5 percent to a complex DNA mixture can be robustly identified even when the starting DNA amount is as little as 5.0 ng and had undergone whole-genome amplification (WGA) prior to SNP analysis. The work presented in this study represents proof-of-principle that the authors previously proposed approach can work with real "forensic-type" samples. Furthermore, in the absence of a low-density focused forensic SNP microarray, the use of standard, currently available high-density SNP microarrays can be similarly used and even increase statistical power due to the larger amount of available information. (Publisher abstract modified)
Downloads
Similar Publications
- Frontal sinus morphology as a forensic identification method: a comparison of intra-observer scores between scout radiographs and 3D skull images
- Exploring the Relationship Between Dental Development, Population Variation, and Environment
- A Systematic Study of Liquid Chromatography to Separate Eighteen Natural Cannabinoids for Potency Testing of Hemp-Based Products Using Diode Array Detector and Electrospray Ionization Mass Spectrometry