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GC–MS Analysis of Gamma-Hydroxybutyric Acid Analogs

NCJ Number
307376
Journal
Journal of Chemical Education Volume: 84 Issue: 11 Dated: 2007 Pages: 1813
Author(s)
Date Published
2007
Annotation

The authors describe an upper-division forensic chemistry experiment using glycolic acid and sodium glicolate to demonstrate the problem with analyzing an organic acid without deritivization and to analyze the products of silylation.

Abstract

This article describes an upper-division forensic chemistry experiment. The experiment involved using glycolic acid and sodium glycolate as analogs of γ-hydroxybutyric acid and its sodium salt; it demonstrated the use of silylation in GC–MS analysis and gave students the opportunity to work with a commonly used silylating reagent, N,O-bis[trimethylsilyl]trifluoroacetamide (BSTFA). GC–MS was used to show the problem with analyzing an organic acid without derivatization and to analyze the products of silylation. Publisher Abstract Provided

Date Published: January 1, 2007