This article reports on a study in which gas chromatography–mass spectrometry (GC–MS) and gas chromatography–infrared detection (GC–IRD) methods were developed and compared for the differentiation of regioisomeric phenethylamines related to methamphetamine.
There are five regioisomeric phenethylamines (methamphetamine and four regioisomers) that produce essentially equivalent mass spectra. This unique set of five phenethylamines having the same molecular weight and elemental composition yield major mass spectral fragments at equivalent mass. The trifluoroacetyl derivatives of the primary and secondary amines yield characteristic individual fragment ions, enabling structural differentiation among these regioisomers. In the current study, the vapor phase infrared spectra generated via capillary gas chromatography differentiated among these compounds without the need for derivatization. The regioisomeric phenethylamines are well resolved by GC with the elution order generally determined by the degree of molecular linearity. (publisher abstract modified)
Downloads
Similar Publications
- Enhancing Our Genetic Knowledge of Human Iris Pigmentation and Facial Morphology
- The Collection, Preservation, and Processing of DNA Samples from Decomposing Human Remains for More Direct Disaster Victim Identification (DVI)
- Post-burn and Post-blast Rapid Detection of Trace and Bulk Energetics by 3D-printed Cone Spray Ionization Mass Spectrometry