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Population Genetics of SNPs for Forensic Purposes

Award Information

Awardee
Yale University
Award #
2007-DN-BX-K197
Funding Category
Continuation
Location

New Haven, CT

Congressional District
3
Status
Closed
Funding First Awarded
2007
Total funding (to date)
$1,152,430
Original Solicitation
NIJ FY 07 Forensic DNA Research and Development: Invited Full Proposals

Description of original award (Fiscal Year 2007, $680,516)

The objectives of the principal investigator's current NIJ grant are to develop two panels of single nucleotide polymorphisms (SNPs) for forensic work. These include a panel for individual identification that would be applicable irrespective of ethnicity, and a panel suitable for refined inference of ancestry. The work performed so far has resulted in an Individual Identification SNP (IISNP) panel of 40 SNPs that provide highly probative match probabilities. The preliminary panel of SNPs to be used for Ancestry Identification (AISNPs) consists of 93 SNPs and is a significant improvement over previous SNP panels in that it is much more robust, identifies five geographic regions, and allows good resolution into populations within some of those regions but not within other regions. Fiscal year 2007 funding will allow the principal investigator to improve these panels in order to increase their utility and facilitate their transfer into operational forensic laboratories.

ca/ncf

The objectives of 2007-DN-BX-K197 are to develop two panels of single nucleotide polymorphisms (SNPs) for forensic work: a panel for individual identification that would be applicable irrespective of ethnicity, and a panel suitable for refined inference of ancestry. The individual identification SNP panel (called the IISNP panel) has been completed. The goal of the continuation is to finalize an optimized panel of SNPs that will allow law enforcement investigators to accurately estimate the ancestral origins of an unknown individual. The final ancestral Identification SNP panel (called the AISNP panel) will be made public immediately upon finalization with all associated allele frequencies.

ca/ncf

Date Created: September 5, 2007