Drugs

With the passage of the 2018 Agricultural Improvement Act (Farm Bill), forensic laboratories have been tasked with differentiating seized cannabis samples as either hemp or marijuana. The new legislation declassified hemp as a Schedule 1 drug substance and defined it as cannabis containing 0.3 % or less of decarboxylated-Δ9-THC (total Δ9-THC). The National Institute of Standards and Technology (NIST) has been working to help forensic laboratories with these challenging measurements through the development of extraction protocols and analytical methods.

The reauthorization of hemp due to the Agriculture Improvement Act of 2018 (Farm Bill) has caused a proliferation of products that contain cannabidiol (CBD). While CBD is considered ‘legal’ under the Farm-Bill, there are concerns that the labeling of CBD products is inaccurate, and that the products may contain other cannabinoids, including Δ9-tetrahydrocannabinol (THC), the main psychoactive compound in marijuana. Other concerns include the potential for conversion of CBD to other cannabinoids during analysis of biological matrices and in acidic foods and beverages.

The Forensic Technology Center of Excellence assisted the National Institute of Justice in hosting the annual NIJ Forensic Science Research and Development Symposium on Tuesday, February 18, 2025 at the 77th Annual American Academy of Forensic Sciences meeting in Baltimore, Maryland. This video is one of five recorded sessions from the event. 

Presentations include -

As evident by the Cannabinoid Connundrums webinar series, the rapidly changing world of cannabinoids offers many conundrums. To tackle some of these questions, Dr. Ruth Winecker led a panel discussion with Dr. Ed Cone, Dr. Nathalie Desrosiers, Mr. Justin Poklis, and Mr. Nelson Santos. This diverse slate of thought leaders includes experts in analytical chemistry, forensic toxicology, clinical research, and drug chemistry. This webinar was hosted by the NIJ Forensic Technology Center of Excellence on August 3, 2023. 

Controlled drug administration studies are valuable tools for acquiring a detailed understanding of the pharmacodynamic and pharmacokinetic profiles of cannabinoids. ∆9-tetrahydrocannabinoid (THC) is the primary psychoactive cannabinoid in cannabis with the potential to negatively impact cognitive and psychomotor performance and workplace safety. These studies establish behavioral and subjective effect profiles while simultaneously collecting pharmacokinetics data.

THC isomers, also known as THC analogs or semi-synthetic cannabinoids, are structurally related to Δ9-tetrahydrocannabinol (Δ9-THC) and have similar toxicity and impairing effects. A recent study indicated that Δ8-THC use was around 27% of marijuana use, based on detection and ratios of cannabinoid metabolites in workplace drug testing. Other analogs of interest include hexahydrocannabinol (HHC) and THC-O. THC isomers are generally perceived as legal and are also seen in states with legal marijuana.

Presenters provided an overview of some of the more unique concealment methods utilized by drug traffickers, as well as some of the sampling and extraction methods used to prepare these submissions for analyses. They also discussed trends associated with counterfeit tablets containing fentanyl seized by the U.S. Drug Enforcement Administration.

This webinar was hosted by the NIJ National Forensic Technology Center of Excellence on May 26, 2022.

With the rise of illicit fentanyl, fentanyl analogues, synthetic cathinones, xylazine, and other substances adulterating many traditional street drugs, users often have no idea what they are consuming, leading to overdose and death.  This further complicates toxicology testing and death determination.  This presentation will cover interesting postmortem case studies from Ohio, Denver, and Miami from the scene perspective through autopsy and toxicology testing.

This presentation will review substance use disorder treatment admissions and impacts on Native people residing in Minnesota. Special attention will be paid to geographic areas of the state impacted and specific illegal substances prominent with Native people in Minnesota using both treatment admission and overdose data.

This webinar was hosted by the NIJ Forensic Technology Center of Excellence on May 10, 2022.

This webinar will focus on the journey through medical marijuana and the decriminalization of hemp with legalization on the horizon in the state of Ohio. We will also focus on the impact that legalization has made in the state of Colorado over the past 10 years. The journey between these two states will demonstrate the challenges and needs for a shift in the analytical approach.

This webinar was hosted by the NIJ Forensic Technology Center of Excellence on April 5, 2022, as part of the ASCLD Train the Director Webinar Series.