Surface-Enhanced Raman Spectroscopy for Trace Identification of Controlled Substances: Morphine, Codeine, and Hydrocodone

• NCJ Number: 233678
• Journal: Journal of Forensic Sciences Volume: 56 Issue: 1 Dated: January 2011 Pages: 200-207
• Author(s): Vinesh Rana, M.A.; Maria V. Canamares, Ph.D.; Thomas Kubic, Ph.D.; Marco Leona, Ph.D.; John R. Lombardi, Ph.D.
• Date Published: January 2011
• Length: 8 pages
• Grant Number(s): 2006-DN-BX-K034; 80209; CHE-0091362; CHE-0345987; ECS0217646; IMR 0526926
• Agencies: NIJ-Sponsored
• Publication Type: Report (Study/Research)
• Award: Development of Advanced Raman Spectroscopy Methods and Databases for the Evaluation of Trace Evidence and the Examination of Questioned Documents

Annotation

This study examined the results of trace identification of controlled substances.

Abstract

The authors obtain the normal Raman and surface-enhanced Raman spectrum of three controlled substances: morphine, codeine, and hydrocodone. The spectra are assigned with the aid of density functional theory. Because of rather intense fluorescence, normal Raman spectra suffer from poor signal-to-noise, even when differential subtraction techniques are employed. On the other hand, surface enhancement by Ag nanoparticles both enhances the Raman signal and suppresses the fluorescence, enabling far more sensitive detection and identification. The authors also present a set of discriminant bands, useful for distinguishing the three compounds, despite the similarities in their structures. (Published Abstract) Figures, tables, and references