N,N-Dimethylpentylone (NPS Stimulant)

• NCJ Number: 307413
• Author(s): Sara E. Walton; Alex J. Krotulski; Melissa F. Fogarty; Donna M. Papsun; Barry K. Logan
• Date Published: 2022
• Length: 13 pages
• Grant Number(s): 2020-DQ-BX-0007
• Agencies: NIJ-Sponsored
• Publication Type: Research (Applied/Empirical)
• Award: Real-Time Sample-Mining and Data-Mining Approaches for the Discovery of Novel Psychoactive Substances (NPS)

Annotation

This purpose for this toolkit is to notify public health and safety, law enforcement, first responders, clinicians, medical examiners and coroners, forensic and clinical laboratory personnel, and all other related communities about new information regarding the emergent synthetic opioid, N,N-Dimethylpentylone.

Abstract

The NPS Discovery Toolkit is a consolidation of The Center for Forensic Science Research and Education (CFSRE) program outcomes into a comprehensive document that provides relevant information about the characterization of a specified novel psychoactive substance (NPS): N,N-Dimethylpentylone. This toolkit includes basic drug information, date of first appearance, prevalence, temporal trends, geographical trends and quarterly reports, demographics, poly-drug combinations (including with other NPS), metabolism, methods for identification and confirmation, reference concentration ranges, and much more. This toolkit is designed to serve as a one-stop resource for scientists and interested individuals looking for all-inclusive information about the new drug, N,N-Dimethylpentylone. The summary of the drug describes its origins and drug analogues, as well as recent in vitro pharmacological data conclusions. The document also provides demographics information from overdose cases; geographic distribution; and recommendations for public health, clinicians, medical examiners (MEs) and coroners, and laboratories. The toolkit also provides current data on the status of NPS opioid prevalence and positivity within the U.S.; drug monograph which includes the chemical formula, molecular weight, exact mass; analytical methods for the analysis of N,N-Dimethylpentylone; related stimulants and their isometric relationships; and data on the suspected metabolism of N,N-Dimethylpentylone, which reports on primary metabolites that were evaluated through in vivo experiments using human liver microsomes.