We describe a procedure to address calculation of match probabilities when casework samples are generated using an MPS kit with different trim sites than those present in the relevant population frequency database.
The first autosomal sequence-based allele (aka SNP-STR haplotype) frequency database for forensic massively parallel sequencing (MPS) has been published, thereby removing one of the remaining barriers to implementing MPS in casework. The database was developed using a specific set of flank trim sites. If different trim sites or different kits with different primers are used for casework, then SNP-STR haplotypes may be detected that do not have frequencies in the database. The proposed procedure provides a framework for comparison of any MPS kit or database combination while also accommodating comparison of MPS and CE profiles. (Publisher abstract provided)
Downloads
Similar Publications
- Electroanalytical Paper-based Sensors for Infield Detection of Chlorate-based Explosives and Quantification of Oxyanions
- Extinction Training Suppresses Activity of Fear Memory Ensembles across the Hippocampus and Alters Transcriptomes of Fear-encoding Cells
- Estimation of Sex Assigned at Birth Using Dental Crown and Cervical Measurements in a Modern Global Sample