In this project, the acetyl, propionyl and trifluoroacetyl derivatives of the primary and secondary regioisomeric amines were prepared and evaluated in GC–MS studies.
A series of side chain regioisomers of 3-methoxy-4-methyl- and 4-methoxy-4-methyl-phenethylamines have mass spectra essentially equivalent to the controlled drug substance 3,4-methylenedioxymethamphetamine (3,4-MDMA); all have molecular weight of 193 and major fragment ions in their electron ionization mass spectra at m/z 58 and 135/136. In the current project, the mass spectra for the acetyl, propionyl, and trifluoroacetyl derivatives of the primary and secondary regioisomeric amines were significantly individualized. The resulting unique fragment ions enabled specific side chain identification. The trifluoroacetyl derivatives provided more fragment ions for molecular individualization among these regioisomeric substances. These trifluoroacetyl derivatives showed excellent resolution on a non-polar stationary phase such as Rtx-1. (publisher abstract modified)
Downloads
Related Topics
MDMA (designer drug)Similar Publications
- Centrifugal Microfluidic Devices Using Low-Volume Reagent Storage and Inward Fluid Displacement for Presumptive Drug Detection
- Passing the Trash: Absence of State Laws Allows for Continued Sexual Abuse of K-12 Students by School Employees
- Product Evaluation of M.M.C. International B.V. Screening Tests for Narcotics - Technology Evaluation