GC-MS, GC-MS/MS and GC-IR Differentiation of Desoxy Cathinone Derivatives: Cyclic Tertiary Amines related to MDPV

• NCJ Number: 251939
• Journal: Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences Volume: 1048 Dated: March 2017 Pages: 38-48
• Author(s): Y. Abiedalla; Jack DeRuiter; C. R. Clark
• Date Published: March 2017
• Length: 11 pages
• Grant Number(s): 2013-DN-BX-K022
• Agencies: NIJ-Sponsored
• Publication Type: Research (Applied/Empirical); Report (Study/Research); Report (Grant Sponsored); Program/Project Description
• Award: Bath Salt-type Aminoketone designer Drugs: Analytical and Synthetic Studies on Substituted Cathinones

Annotation

This article reports on a study that compared the analytical properties of a series of cyclic tertiary aminoketones and the corresponding desoxy phenethylamines

Abstract

The desoxy phenethylamine analogues in this study represent a combination of alkyl side-chain and cyclic amines (azetidine, pyrrolidine, piperidine and azepane) to yield a set of molecules of identical elemental composition as well as major mass spectral fragment ions (base peaks) of identical elemental composition. These desoxy phenethylamine analogues of the aminoketone designer drug, 3,4-methylenedioxy-pyrrovalerone (MDPV) related to the natural product cathinone were prepared from piperonal (3,4-methylenedioxybenzaldehyde) via the intermediate precursor ketones. The aminoketones and the desoxy phenethylamine regioisomers were each separated in capillary gas chromatography experiments using an Rxi-17Sil MS stationary phase with the aminoketones showing greater retention than the corresponding desoxyamines. (Publisher abstract modified)