This paper reports on an examination of father-son sample pairs to identify mutations using the 17 Y-STR loci in the Yfiler™ kit, with a discussion of research results.
The authors have examined 389 father-son sample pairs from U.S. Caucasians, African Americans, Hispanics, and Asians using the 17 Y-STR loci in the Yfiler™ kit and observed a total of 24 differences between father and son. Thirteen mutations resulted in the gain of a repeat in the son and 11 resulted in a loss of a repeat. All samples resulted in single repeat mutations except one sample which contained a two-repeat loss at Y-GATA-H4. Furthermore, two different sample pairs were found to have two mutations. An African American sample pair had a mutation at DYS458 and a second at DYS635 and an Asian sample pair had mutations at DYS439 and Y-GATA-H4. (Published Abstracts Provided)
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