Description of original award (Fiscal Year 2010, $363,613)
A variety of solutions to address the limited quantity of low quality DNA have been pursued, including in vitro DNA repair and whole genome amplification (WGA); however, neither of these methods has been implemented on an operational scale. To employ these methods, it is necessary to determine if DNA repair or WGA introduce errors that affect the reliability of DNA typing results. The researchers propose to determine whether DNA repair (commercially available PreCR DNA repair enzyme cocktail) or WGA (REPLI-g® kit) introduce unacceptable levels (or undetectable) of DNA sequence alteration and to determine which inhibitory compounds and/or sample types most significantly affect the performance of DNA repair and WGA.
- Capturing nuclear DNA from hair shafts
- Expanding Mental Health Diversion Opportunities: A Prospective Evaluation of the Los Angeles County Intake Booking Diversion Program
- Losing Sleep and Losing Control: The Impact of Subjective and Objective Sleep on the Problem Behavior and Mental Health of Justice-Involved Young Adults