Description of original award (Fiscal Year 2010, $397,098)
The researchers propose to evaluate two newly emerging methods of DNA sequence analysis to obtain massively parallel mtDNA sequence information (deep sequencing) from hair, buccal, and blood samples. The expanded information available from deep mtDNA sequence analysis will reveal whether or not interpretational changes in forensic mtDNA analysis of such samples are necessary, as well as the extent to which deep sequencing can offer a window into a level of variation that is currently underappreciated in forensic casework. This effort will also reveal the general level of sequence heteroplasmy present in hair samples as compared to blood and buccal samples, all common targets of forensic mtDNA analysis.
- Mitogenome Sequencing of 10,000 Population Samples Using a Highly Accurate, Single-Molecule Approach
- Understanding the Criminal Justice and Health Care Needs of Latinx Victims of Hate Crime and Bias Victimization
- Comparative Evaluation of Massively Parallel Sequencing STR kits with the Emphasis on Mixture Deconvolution Utilizing Probabilistic Genotyping.