In 2010, the National Institute of Justice (NIJ) undertook five strategic challenges to reduce crime and promote justice. These five challenges were fostering science-based criminal justice practice, translating knowledge to practice, advancing technology, working across disciplines, and adopting a global perspective. This report presents a sample of the work performed by NIJ in these five challenge areas. In the area of fostering science-based criminal justice practice, work was done on civil protective orders, use of force, evaluation of automatic license plate reader technology, evaluation of school based anti-bullying programs, reentry, and evaluations of Hawaii HOPE. In the area of translating knowledge to practice, work was done on elder abuse, predictive policing, and forensic science training and cold case funding. In the area of advancing technology, work was undertaken on DNA testing backlog, post-conviction DNA, new forensics tools to detect hidden graves, communications technology, hazardous materials standards, and the National Missing and Unidentified Persons System. In the area of working across disciplines, work was undertaken on officer safety on the roads, a survey of unanalyzed law enforcement evidence, and electronic monitoring. Appendixes to this report include data on NIJ funding.