These two substances are directly available from indole using identical precursor reagents and similar reaction conditions. Stable isotope deuterium labeling of the three major regions of the JWH-018 molecule allows confirmation of the structures of the major fragment ions. The spectra for the 1-n-pentyl-3-(1-naphthoyl)-d5-indole, 1-n-pentyl-3-(1-d7-naphthoyl)indole and 1-d11-n-pentyl-3-(1-naphthoyl)indole provide significant assistance in elucidating the structures for the major fragment ions in JWH-018. The study found that the EI mass spectra for these isomers show a number of unique ions which allow for the differentiation of the 1-alkyl-3-acylindole compounds from the inverse regioisomeric 1-acyl-3-alkylindoles. The fragment ion [M-17]+ at m/z 324 for JWH-018 was formed by the elimination of a hydroxyl radical and the spectra of the three deuterium-labeled derivatives indicated the loss of hydrogen from the naphthalene ring. Further structural analogues suggest the hydrogen comes from the 8-position of the naphthalene ring. The three deuterium-labeled analogues provide significant assistance in confirming the structures for the major fragment ions in the mass spectrum of the traditional synthetic cannabinoid compound, 1-n-pentyl-3-(1-naphthoyl)indole, JWH-018. The 1-naphthoyl-3-n-pentylindole inverse regioisomer can be easily differentiated from the traditional synthetic cannabinoid compound. (Publisher abstract modified)
Downloads
Similar Publications
- High-throughput LC-PDA Method for Determination of Δ9-THC and Related Cannabinoids in Cannabis Sativa
- OpenSense: An Open-World Sensing Framework for Incremental Learning and Dynamic Sensor Scheduling on Embedded Edge Devices
- Race and Rationality Revisited: An Empirical Examination of Differential Travel Patterns to Acquire Drugs Across Geographic Contexts