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Identification of MDMB-FUBINACA in Commercially Available E-liquid Formulations Sold for Use in Electronic Cigarettes

NCJ Number
252371
Date Published
Author(s)
Michelle R. Peace, Rose I. Krakowiak, Carl E. Wolf, Alphonse Poklis, Justin L. Poklis
Annotation
This article reports on a project that identified designer drug MDMB-FUBINACA - chemical name methyl (S)-2-(1-(4-fluorobenzyl)-1H-indazoli-3-carboxamido)-3,3-dimethlylbutanoate – in three commercially available e-liquids formulated for electronic cigarette use.
Abstract
The e-liquids were evaluated using direct analysis in real time ion source attached to a time of flight mass spectrometer (DART-MS) and gas chromatograph mass spectrometer (GC–MS) to identify active ingredients/drugs, flavorants, and other possible constituents. The e-liquids were also evaluated for alcohol content by headspace gas chromatography with flame ionization detector (HS-GC–FID). The aerosol produced from the e-liquids by use of an e-cigarette was analyzed by solid phase micro-extraction gas chromatography mass spectrometry (SPME–GC–MS) to ensure delivery of the active ingredient/drug. Propylene glycol, vegetable glycerin, MDMB-FUBINACA, alcohol content and a flavor profile were determined for each of the e-liquids. MDMB-FUBINACA was determined to be the major active ingredient in all three e-liquids and was successfully detected by SPME–GC–MS in the aerosol generated by a KangerTech Aerotank clearomizer/electronic cigarette. 1 graphical abstract (Publisher abstract modified)
Date Created: April 30, 2019