According to the CDC, there were an estimated 107,622 drug overdose deaths in the U.S. in 2021, an increase of nearly 15% from the 93,655 deaths estimated in 2020. Of the 2021 deaths, almost 81,000 were attributable to opioids, primarily fentanyl. The CDC notes that deaths from “psychostimulants,” such as Ecstasy and cocaine, also increased in 2021 compared to 2020. The NIJ-supported NPS Discovery, run by the Center for Forensic Science and Research Education, serves as a drug early warning system for public health officials, emergency room physicians, crime labs, law enforcement agencies, and others. NPS Discovery screens all the drug samples sent to the program for identification and toxicity. While they examine a wide range of drugs, including the new wave of designer drugs, the focus is on the opioids laced with the fentanyl and nitazene analogs, which have higher risks of killing people.