NCJ Number
195249
Date Published
January 2002
Length
6 pages
Annotation
This research performed a randomized, cross-over controlled trial to assess the effect of Oleoresin capsicum (OC) spray inhalation on respiratory function by itself and combined with restraint.
Abstract
A total of 35 subjects were exposed to OC or placebo spray,
followed by 10 minutes of sitting or prone maximal restraint
position (PMRP). Spirometry, oximetry, and end-tidal CO2 levels
were collected at baseline and throughout the 10 minutes. Data were
compared between groups and with predefined normal values. While
in the sitting position, OC did not result in any significant
changes in mean percent predicted forced vital capacity
(%predFEV), percent predicted forced expiratory volume in 1 s
(%predFEV1), oxygen, or CO2 levels. In the PMRP, mean %predFVC
and %predFEV1 fell 14.4 and 16.5 percent for placebo and 16.2 and
19.1 percent for OC, but were not significantly different by
exposure. There was no evidence of hypoxemia or hypercapnia in
either group. OC exposure did not result in abnormal spirometry,
hypoxemia, or hypoventilation when compared to the placebo in
either sitting or PMRP. Limitations of this study are noted. 2
tables, 2 figures, and 30 references
Date Published: January 1, 2002
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