Current State of Knowledge on Implications of Gut Microbiome for Surgical Conditions

• NCJ Number: 253160
• Journal: Journal of Gastrointestinal Surgery Volume: 22 Issue: 6 Dated: 2018 Pages: 1112-1123
• Author(s): Edmund B. Chen; Cori Cason; Jack A. Gilbert; Karen J. Ho
• Date Published: 2018
• Length: 12 pages
• Grant Number(s): 2017-MU-MU-0042; 2017-MU-MU-4042
• Agencies: NIJ-Sponsored
• Publication Type: Research (Applied/Empirical); Report (Study/Research); Report (Grant Sponsored); Program/Project Description
• Award: Linking internal organ microbiome and metabolome compositions to cause death in medicolegal investigations; Linking Internal Organ Microbiome and Metabolome Composition to Cause of Death in Medicolegal Investigations

Annotation

This article provides a broad overview of the current state of knowledge on the implications of gut microbiome for surgical conditions, and the technology that helped in their formation is reviewed.

Abstract

The role of the microbiome in human health has become a central tenant of current medical research, infiltrating a diverse disciplinary base whereby microbiology, computer science, ecology, gastroenterology, immunology, neurophysiology and psychology, metabolism, and cardiovascular medicine all intersect. Traditionally, commensal gut microbiota have been assumed to play a significant role only in the metabolic processing of dietary nutrients and host metabolites, the fortification of gut epithelial barrier function, and the development of mucosal immunity; however, over the last 20 years, new technologies and renewed interest have uncovered a considerably broader influence of the microbiota on health maintenance and disease, many of which are of particular relevance for surgeons. (publisher abstract modified)