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Complete Mitochondrial DNA Genome Variation in the Swedish Population

NCJ Number
Genes Volume: 14 Issue: 11 Dated: Nov 2023 Pages: 1989
Date Published
November 2023

In this study, the authors performed a detailed evaluation of mitochondrial DNA variation in Sweden at the highest resolution based on high-quality mitogenome haplotypes from the whole genome sequencing; here, the authors report on their research methodology and outcomes.


The development of complete mitochondrial genome (mitogenome) reference data for inclusion in publicly available population databases is currently underway, and the generation of more high-quality mitogenomes will only enhance the statistical power of this forensically useful locus. To characterize mitogenome variation in Sweden, the mitochondrial DNA (mtDNA) reads from the SweGen whole genome sequencing (WGS) dataset were analyzed. To overcome the interference from low-frequency nuclear mtDNA segments (NUMTs), a 10 percent variant frequency threshold was applied for the analysis. In total, 934 forensic-quality mitogenome haplotypes were characterized. Almost 45 percent of the SweGen haplotypes belonged to haplogroup H. Nearly all mitogenome haplotypes (99.1 percent) were assigned to European haplogroups, which was expected based on previous mtDNA studies of the Swedish population. There were signature northern Swedish and Finnish haplogroups observed in the dataset (e.g., U5b1, W1a), consistent with the nuclear DNA analyses of the SweGen data. The complete mitogenome analysis resulted in high haplotype diversity (0.9996) with a random match probability of 0.15 percent. Overall, the SweGen mitogenomes provide a large mtDNA reference dataset for the Swedish population and also contribute to the effort to estimate global mitogenome haplotype frequencies. (Published Abstract Provided)

Date Published: November 1, 2023