This project compared single quadruple mass spectrometry and diode array-ultraviolet (PDA-UV) detection interfaced to ultra-high performance supercritical fluid chromatography for the quantitative analysis of synthetic cathinones.
Synthetic cathinones, also known as bath salts, are derived from cathinone, a component of the khat plant. For 15 controlled solutes linearity, repeatability, and limits of detection were determined using both UV and MS detection. Quantitation studies were performed, using the above detectors for 19 mixtures of up to 4 of the above compounds with an adulterant to simulate seized samples. MS detection provided approximately an order of magnitude greater linearity range and allowed for two to three orders of magnitude lower limits of detection than UV detection. Both detection techniques exhibited similar results of analysis and comparable repeatability. The latter detection mode which provided significantly high linearity correlation coefficients would be preferred for quantitative analysis. (publisher abstract modified)
Downloads
Similar Publications
- Targeted-Ion Mass Spectrometry for the Identification of Forensically Relevant Biological Fluids and Samples from Sexual Assault Evidence
- Forensic Reconstruction of Severely Degraded License Plates
- Utilizing Derivatizing Agents for the Differentiation of Cannabinoid isomers in Complex Food, Beverage and Personal-care Product Matrices by Ambient Ionization Mass Spectrometry