All powdered drug evidence samples examined were correctly identified by the commercial library, showing high promise for use in routine drug evidence screening. The ability for in-source fragmentation and structural isomers to produce false positive/negative responses was also investigated. Samples of interest included 25 positive controls, 4 negative controls, and 3 samples of authentic powder-based drug evidence. Of the 69 MS/MS spectra collected at varying collision-induced dissociation (CID) energies for the positive control samples, 68 of the spectra produced relative average match probabilities (ramp) values high enough to result in "true positive" identifications for all 25 samples tested. None of the negative control samples resulted in false-positive identifications when both obtained ramp values and visual comparison of spectra were considered. (Publisher abstract modified)
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