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4F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework

NCJ Number
Date Published
11 pages
Aex J. Krotulski; Amanda L.A. Mohr; Sherri L. Karinko; Melissa F. Fogarty; Sarah A. Shuda; Francis S. Diamond; William A. Kinney
Publication Type
Research (Applied/Empirical), Report (Study/Research), Report (Grant Sponsored), Program/Project Description
Grant Number(s)
This is the first report regarding the characterization of the new synthetic cannabinoid 4F-MDMB-BINACA.
4F-MDMB-BINACA was first analytically confirmed in seized drug material using gas chromatography-mass spectrometry (GC-MS), liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF), and nuclear magnetic resonance (NMR) spectroscopy. Subsequent to this characterization, 4F-MD-MB-BINACA was detected in biological specimens collected as part of forensically relevant casework, including medicolegal death investigations and drug impaired driving investigations, from a variety of regions in the United States. Further analysis of biological specimens resulted in the identification of the metabolites 4F-MDMB-BINACA 3,3-dimethylbutanoic acid and 4-OH-MDMB-BINACA. 4F-MDMB-BINACA is appearing with increasing frequency as a contributory factor in deaths, creating morbidity and mortality risks for drug users. Laboratories must be aware of its presence and impact, incorporating 4F-MDMB=BINACA into workflows for detection and confirmation. (publisher abstract modified)
Date Created: July 20, 2021