Typing Highly Degraded DNA Using Circularized Molecules and Target Enrichment

Genetic typing of severely damaged DNA remains a challenge. The applicant proposes research to create an approach that would allow genetic typing of degraded DNA that is not possible today. The research will explore the use of circularized molecules and target enrichment techniques to overcome this challenge. "Note: This project contains a research and/or development component, as defined in applicable law," and complies with Part 200 Uniform Requirements - 2 CFR 200.210(a)(14). nca/ncf