Investigating Unexplained Deaths through Molecular Autopsies

In this application, the researchers propose to sequence the entire coding regions of 52 candidate genes believed to be involved in sudden unexplained deaths in 200 samples, as well as sequence all identified variants in an additional 50 cases and 1,000 gender and ethnically matched controls. Data will be evaluated for new variants as well as combinations of variants that alone may not be disease causing, but in concert may predispose victims to sudden death. To achieve these goals, the authors propose to use the massive parallel sequencing technology available in next generation sequencing platforms. ca/ncf