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Prediction of drug interactions with methadone, buprenorphine and oxycodone from in vitro inhibition of metabolism

Award Information

Award #
2011-DN-BX-K532
Funding Category
Competitive
Location
Congressional District
Status
Closed
Funding First Awarded
2011
Total funding (to date)
$1,058,604

Description of original award (Fiscal Year 2011, $1,058,604)

This project will explore the use of liquid chromatographic-tandem mass spectrometric (LC-MS/MS) assays to study the in vitro metabolism of methadone, buprenorphine and oxycodone. The goal of this project is to better understand metabolism inhibition rates of specific compounds while in the prescence of other drugs.

ca/ncf

Date Created: September 15, 2011