U.S. flag

An official website of the United States government, Department of Justice.

Dot gov

The .gov means it’s official.
Federal government websites always use a .gov or .mil domain. Before sharing sensitive information online, make sure you’re on a .gov or .mil site by inspecting your browser’s address (or “location”) bar.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Designer Amphetamines in Forensic Toxicology: Analysis and Prevalence

Award Information

Award #
2008-DN-BX-K126
Location
Awardee County
Walker
Congressional District
Status
Closed
Funding First Awarded
2008
Total funding (to date)
$466,492

Description of original award (Fiscal Year 2008, $226,550)

This project seeks to develop screening and confirmatory methods for new, emerging 'designer' amphetamines, using the most widely used technologies in forensic toxicological laboratories today, specifically enzyme-linked immunosorbent assay (ELISA) and gas chromatography/mass spectrometry (GC/MS). The cross-reactivity of antibodies used in commercial immunoassays for methamphetamine will be examined to determine whether existing commercial immunoassays are effective screening tools for emerging designer drugs. Extraction protocols and chemical derivatives will be considered in order to develop a confirmatory analysis using GC/MS, taking into consideration existing resources that do not place an undue burden on the laboratory or require extensive familiarization. The resulting procedures will be scientifically validated according to established procedures and accreditation requirements. Such validated procedures, using commonly used technologies and methodologies, will assist in reducing case backlog in the area of forensic toxicology. Finally, prevalence of these drugs in actual forensic toxicology casework samples will be investigated.

ca/ncf

This award will provide funding to Sam Houston State University to expand research of emerging designer amphetamines in casework, by increasing the number of targeted drugs from 10 to as many as 27, and by examining the prevalence of the targeted compounds in more case samples, from 500 cases to 2500 cases, drawn from a wider geographic area. The extension of this research will provide routine testing laboratories with practical information that will allow them to implement new analytical procedures for the detection of the newer designer amphetamines. This will reduce case backlog by allowing for testing for more compounds with one test.

ca/ncf

Date Created: September 15, 2008