A SNP-Based Microarray Technology For Use In Forensic Applications

Single nucleotide polymorphisms (SNPs) are the most frequent form of DNA sequence variation in the human genome. Analysis of a battery of SNPs can augment STR data as well as provide additional information about the source of DNA samples, such as hair-color, eye-color, and ancestry. The objective of this project is to develop an accurate and affordable microarray technique for the analysis of SNPs in forensic evidence. It will focus on applying and optimizing the Affymetrix technology for forensic applications, and will include: single donor samples, mixture analysis of multiple DNA sources in one sample, and forensically useful sample quantities. ca/ncf