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An Update on the Presence of BTMPS in the Drug Supply and the Discovery of Tetramethylfentanyl-Related Substances

NCJ Number
311074
Date Published
May 2025
Abstract

BTMPS has been detected in all regions across the United States, demonstrating vast prevalence. BTMPS has appeared in more than 600 drug materials tested by our laboratory. Tetramethyl-4-piperidinol (TMP) was first detected in August 2024 and since has appeared in more than 20 drug materials. Tetramethyl-4-AP (TM-4-AP) and tetramethylnorfentanyl (TMNF) were first detected in April 2025 and since have appeared in more than ten drug materials, often together. To date, a substance suspected of being tetramethylfentanyl (TMF) has been identified in only small (or trace) amounts alongside these other related substances; however, confirmation of this substance is pending acquisition of standard reference material.

(Publisher abstract provided.)

Date Published: May 1, 2025