Microhaplotypes in forensic genetics

• NCJ Number: 253976
• Journal: Forensic Science International-Genetics Issue: 38 Dated: January 2019 Pages: 54-69
• Author(s): Fabio Oldoni; Kenneth K. Kidd; Daniele Podini
• Date Published: January 2019
• Length: 16 pages
• Grant Number(s): 2017-DN-BX-0164; 2015-DN-BX-K023
• Agencies: NIJ-Sponsored
• Publication Type: Research (Applied/Empirical); Report (Study/Research); Report (Grant Sponsored); Program/Project Description
• Award: Powerful Forensic Markers Optimized for Massively Parallel Sequencing; Massively parallel sequencing of 89 microhaplotypes for the selection of an operational and effective subset for forensic applications.

Annotation

Since microhaplotype loci (microhaps, MHs) are a novel type of molecular marker of less than 300 nucleotides, defined by two or more closely linked SNPs associated in multiple allelic combinations, the current review describes the features of these multi-SNP markers and documents their value in forensic genetics

Abstract

The review focused on individualization, biogeographic ancestry inference, and mixture deconvolution. Foreseeable applications also include missing person identification, relationship testing, and medical diagnostic applications. The technique is not restricted to humans. (publisher abstract modified)