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A Low Cost Microfluidic Instrument for Typing SNPs

Award Information

Award #
2009-DN-BX-K189
Funding Category
Competitive
Location
Congressional District
Status
Closed
Funding First Awarded
2009
Total funding (to date)
$495,031

Description of original award (Fiscal Year 2009, $495,031)

The goal of this work is to design, build, and test an integrated microfluidic controlled microarray test for single nucleotide polymorphism (SNP) typing. Akonni previously demonstrated the feasibility of a gel drop microarray platform as a complete solution for forensic SNP-typing applications. Sample preparation, polymerase chain reaction (PCR), and the microarray were packaged into prototype flow-through microfluidic modules for Y-chromosome SNP determination. The current work will focus on: 1) refining protocols and assay chemistries and 2) packaging components and reagents into an integrated system for automated, sample-to-answer results.

ca/ncf

Date Created: September 22, 2009