When CODIS software recognizes the same DNA profile in the Forensic or Offender Index, it identifies the two profiles as a match. These matches are commonly referred to as "hits."

After CODIS software produces a hit, qualified laboratory personnel analyze the DNA samples to either validate or refute the match. This is usually done as a precautionary measure to make sure there are no problems with data entry. There are times, however, when the DNA profile found on crime scene evidence is a mixture of more than one person's DNA. In that case, analysts must compare profiles to see if the individual's profile is part of the mixed DNA.

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