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NIJ seeks proposals for research to examine whether the physiologic and metabolic effects of the stress of being subdued or restrained, by any means, may explain otherwise unexplained in-custody deaths. Specifically, NIJ seeks proposals for research to: (1) clarify the fatal mechanisms that might be associated with stress resulting from being subdued or restrained, by any means and not limited to CEDs; and, if such mechanisms can be demonstrated, (2) identify post-mortem markers that can inform death investigations. View frequently asked questons related to this solicitation.