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A Large-scale Survey of the Postmortem Human Microbiome, and Its Potential to Provide Insight Into the Living Health Condition

NCJ Number
253358
Date Published
2018
Length
8 pages
Author(s)
Jennifer L. Pechal; Carl J. Schmidt; Heather R. Jordan; M. E. Benbow
Agencies
NIJ-Sponsored
Publication Type
Research (Applied/Empirical), Report (Study/Research), Report (Grant Sponsored), Program/Project Description
Grant Number(s)
2014-DN-BX-K008
Annotation
This study revealed distinct postmortem microbiomes of human hosts from a large-scale survey of death cases representing a predominantly urban population, and it demonstrated that these microbiomes reflected antemortem health conditions within 24 hours of death.
Abstract
The microbiome plays many roles in human health, often through the exclusive lens of clinical interest. The inevitable end point for all living hosts, death, has its own altered microbiome configurations; however, little is understood about the ecology and changes of microbial communities after death, or their potential utility for understanding the health condition of the recently living. Results of the current study characterized microbial community structure and predicted function from 188 cases representing a cross-section of an industrial-urban population. The study found strong niche differentiation of anatomic habitat and microbial community turnover based on topographical distribution. Microbial community stability was documented up to 2 days after death. In addition, the study found a positive relationship between cell motility and time since host death. There was evidence that microbial biodiversity is a predictor of antemortem host health condition (e.g., heart disease). These findings improve the understanding of postmortem host microbiota dynamics and provide a robust dataset to test the postmortem microbiome as a tool for assessing health conditions in living populations. (publisher abstract modified)
Date Created: July 20, 2021